Course: Epidemiology of Infectious Diseases

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Kenrad E. Nelson & Carolyn Masters Williams. Infectious Disease Epidemiology: Theory and Practice. Second Edition. Jones and Bartlett Publishers, 2006.

This text is designed to be used in the course; book chapters have been written by the course lecturers.

Topic Readings
Overview of Microbiology

Ksiazek TG, Erdman D et al. A novel coronavirus associated with severe acute respiratory syndrome. New Engl J Med 2003;348(20):1953-1966

The Molecular Epidemiology of Infectious Disease

van rie A, Warren R, Richardson M, Victor TC, Gie RP, Enarson DA, Beyers N, van Helden PD. Exogenous reinfection as cause of recurrent tuberculosis after curative treatment. New Engl J Med 1999;341(15):1174-1179.

Modeling of Infectious Disease

Huges JP, Garnett GP, et al. The theoretical population-level impact of a prophylactic human papilloma virus vaccine. Epidemiology 2002; 13:631-639.

Case-Control Studies

Arcari C, Gaydos CA , Nieto FJ, Krauss M and Nelson KE. Association between Chlamydia pneumoniae and acute myocardial infarction in young men in the United States military: the importance of timing of exposure measurement. Clin Infect Dis 2005; 40:1123-30.

Wheeler C, Vogt TM, Armstrong GL et al. An outbreak of hepatitis A associated with green onions. N Engl J Med 2005; 353:890-7.

Vaccines - Impact, Questions, and Challenges

Harper DM, Franco EL. Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infectin with human papillomavirus types 16 and 18 in young women: a randomized controlled trial. Lancet 2004 (364):1757-1765.


Parker AA, Staggs W, et al. Implications of a 2005 measles outbreak in Indiana for sustained elimination of measles in the United States . New Engl J Med 2006;355(5):447-455.

Disease Eradication

Alexander LN , Seward JF, et al. Vaccine policy changes and epidemiology of poliomyelitis in the United States . JAMA 2004; 292:1696-1701.

Beyond Osler: The Past, Present, and Future of Infection Control

Srinivasan A, Wolfenden LL, Song X, Mackie K, Hartsell TL, Jones HD, Diette GB, Orens JB, Yung RC, Ross TL, Merz W, Scheel PJ, Haponik EF, Perl TM.. An outbreak of Pseudomonas aeruginosa infections associated with flexible bronchoscopes. N Engl J Med 2003;348:91-2.

Interactions between Nutrition and Infection in the Developing World

Fawzi WW, Masamanga GI, Spielman D, et al. A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med 2004; 351:23-32

Epidemiology of Diarrheal Diseases

Woo PCY, Lau SKP, et al. Association of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: a multicentre case control study. Lancet 2004 (363) 1941-1947.

TB Epidemiology

Weis SE, Slocum Pc, Blais FX, King B, Nunn M, et al. the effect of directly observed therapy on the rates of drug resistance and relapse in tuberculosis. N Engl J Med 1994; 330:1179-1184.

Influenza: Virus and Disease, Epidemics and Pandemics

Horwitz ES, Haber M, Chang A, Shope T, Teo S, Ginsberg M, Waecker N, Cox NJ. Effectiveness of influenza vaccination of day care children in reducing influenza-related morbidity among household contacts. JAMA 2000; 284:1677-1682.

CNS Viral Infections

Stramer SL, Fang CT, Foster GA, Wagner AG, Brodsky JP, Dodd RY. West Nile virus among blood donors in the United States . N Engl J Med 2005; 353:451-9.

Lyme Disease and Its Epidemiology

Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig EL Schoen RT, Nowakowski J, Schmid CH, Laukamp S, Buscarino C, Krause DS. Lyme Disease Vaccine Study Group. Vaccination against lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. NEJM 1998; 339(4):209-215.

Meningococcal Disease: Global Problem, Local Solutions

Imrey PB, Jackson LA, Ludwinski PH, et al. Outbreak of serogroup C meningococcal disease associated with campus bar patronage. Am J Epidemiol 1996;143:624-30.

Epidemiology and Control of Malaria

Alonso PI, Sacarlal J, et al. Efficacy of the RTS,S/ASO2A vaccine against Plasmodium falciparum infection and disease in young African children : randomised controled trial. Lancet 2004 (364):1411-1420.

STD Epidemiology

Wawer MJ, RH Gray et al. Rates of HIV-1 transmission per Coital Act, by state of HIV-1 infection, in Rakai , Uganda . JID 2005:191:1403-1409.

The Epidemiology of Hepatitis B and A Infections

Chang M-H, Chen C-J, Lai M-S, Hsu H-M, Wu T-C, Kong M-S, Liang D-C, Shau W-Y, Chen D-S, Taiwan Childhood Hepatoma Study Group. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. NEJM 1997; 336:1855-1859.

Hepatitis C and E

El-Serag HB, Davila JA, Peterson NJ, McGlynn KA. The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med 2003;139:817-823.

El-Serag HB, Mason AC. Risk factors for the rising rates of primary liver cancer in the United States . Arch Intern med 2000; 160:3227-30.