Course: Reproductive and Perinatal Epidemiology

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Topic Readings
Lecture 1: Physiology and Introduction to Reproductive Health

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Lecture 2: Conception and Pregnancy Loss

Wilcox AJ, et al. The timing of the "fertile window" in the menstrual cycle: day specific estimates from a prospective study.
BMJ. 2000 Nov 18;321(7271):1259-62.

Nichols HB, Trentham-Dietz A, Hampton JM, Titus-Ernstoff L, Egan KM, Willett WC, Newcomb PA. From menarche to menopause: trends among US Women born from 1912 to 1969. Am J Epidemiol. 2006 Nov 15;164(10):1003-11. Epub 2006 Aug 23.

Discussion Questions

Lecture 3: Female and Male Infertility

Schieve LA, et al. Low and very low birth weight in infants conceived with use of assisted reproductive technology. N Engl J Med. 2002 Mar 7;346(10):731-7.

Jain T, Missmer SA, Hornstein MD. Trends in embryo-transfer practice and in outcomes of the use of assisted reproductive technology in the United States. N Engl J Med. Apr 15 2004;350(16):1639-1645.

Discussion Questions

Lecture 4: Contraception Evaluation

Hubacher D, et al. Use of copper intrauterine devices and the risk of tubal infertility among nulligravid women. N Engl J Med. 2001 Aug 23;345(8):561-7.

Darney PD. Time to pardon the IUD? N Engl J Med. 2001 Aug 23;345(8):608-10.

Joyce T, Kaestner R, Colman S. Changes in abortions and births and the Texas parental notification law. N Engl J Med. 2006 Mar 9;354(10):1031-8.

Discussion Questions

Lecture 5: Adverse Effects of Hormonal Contraception and Hormone Supplementation

Acute myocardial infarction and combined oral contraceptives: results of an international multicentre case-control study. WHO Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Lancet. 1997 Apr 26;349(9060):1202-9.

Khader YS, Rice J, John L, Abueita O. Oral contraceptives use and the risk of myocardial infarction: a meta-analysis. Contraception. Jul 2003;68(1):11-17.

Beral V, Hermon C, Kay C, Hannaford P, Darby S, Reeves G. Mortality associated with oral contraceptive use: 25 year follow up of cohort of 46 000 women from Royal College of General Practitioners' oral contraception study. BMJ. Jan 9 1999;318(7176):96-100.

Discussion Questions

Lecture 6: Female and Male Reproductive Tract Cancers I

Chlebowski RT, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial. JAMA. 2003 Jun 25;289(24):3243-53.

Discussion Questions

Lecture 7: Female and Male Reproductive Tract Cancers II

Tannock IF. Eradication of a disease: how we cured symptomless prostate cancer. Lancet. 2002 Apr 13;359(9314):1341-2.

Holmberg L, et al. A randomized trial comparing radical prostatectomy with watchful waiting in early prostate cancer. N Engl J Med. 2002 Sep 12;347(11):781-9.

Discussion Questions

Lecture 8: Complications of Labor/Delivery and Maternal Mortality

Hill K, et al. How should we measure maternal mortality in the developing world? A comparison of household deaths and sibling history approaches. Bulletin of the World Health Organization 2006;84:173-180

Derman RJ, et al. Oral misoprostol in preventing postpartum haemorrhage in resource-poor communities: a randomised controlled trial. The Lancet 2006;368:1248-1253

Discussion Questions

Lecture 9: HIV and STDs in Pregnancy

Klebanoff MA, et al. Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection. N Engl J Med. 2001 Aug 16;345(7):487-93.

Kigozi GG, et al. Treatment of Trichomonas in pregnancy and adverse outcomes of pregnancy: a subanalysis of a randomized trial in Rakai , Uganda . Am J Obstet Gynecol. 2003 Nov;189(5):1398-400.

Discussion Questions

Lecture 10: Epidemiology of LBW, PTD, IUGR I

Dole N, Savitz DA, Hertz-Picciotto I, Siega-Riz AM, McMahon MJ, Buekens P. Maternal stress and preterm birth. Am J Epidemiol. Jan 1 2003;157(1):14-24.

Copper et al. The preterm prediction study: Maternal stress is associated with spontaneous preterm birth at less than thirty-five weeks'gestation. Am J Obstet Gynecol 1996;175:1286-92

Discussion Questions

Lecture 11: Epidemiology of LBW, PTD, IUGR II

Christian P et al. Effects of alternative maternal micronutrient supplements on low birth weight in rural Nepal : double blind randomized community trial. BMJ. 2003 Mar 15;326(7389):571.

Fawzi WW et al. Randomized trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet. 1998;351:1477-82.

Villar J, Ba'aqeel H, Piaggio G, Lumbiganon P, Miguel Belizan J, Farnot U, et al. WHO0 antenatal care randomised trial for the evaluation of a new model of routine antenatal care. Lancet. May 19 2001;357(9268):1551-1564.

Discussion Questions

Lecture 12a: Complications of Pregnancy

Seth SS, Chalmers I. Magnesium for preventing and treating eclampsia: time for international action. Lancet. 2002 Jun 1;359(9321):1872-3.

Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J, Smith D; Magpie Trial Collaboration Group. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet. 2002 Jun 1;359(9321):1877-90.

Lecture 12b: Congenital Malformations, Stillbirths and Perinatal Deaths

Hansen M. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med. 2002 Mar 7;346(10):725-30.

Discussion Questions

Lecture 13: Neural Tube Defects

Mills JL, Signore C. Neural Tube Defect Rates before and after Food Fortification with Folic Acid. Birth Defects Research (Part A) 70:844�845 (2004)

Rader JI, Schneeman BO. Prevalence of Neural Tube Defects, Folate Status, and Folate Fortification of Enriched Cereal-Grain Products in the United States . Pediatrics 2006;117;1394-1399

Brent RL, Oakley GP. The Folate Debate. Pediatrics 2006;117;1418-1419

Discussion Questions

Lecture 14: Violence against Women and Reproductive Outcomes

Koenig M.A., Zablotska I., Lutalo T., Nalugoda F., Kiwanuka N., Serwadda D., Wawer M., and Gray R. Coerced First Intercourse and Reproductive Health among Adolescent Women in Rakai, Uganda. IFPP 2004;30:156-63.

Ahmed S, Koenig MA, Stephenson R. Effects of domestic violence on perinatal and early childhood mortality: evidence from north India . Am J Public Health. 2006 Aug; 96(8):1423-8.

Discussion Questions